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During neuropathy, the numbers of ionized calcium binding adapter molecule 1 (Iba1) (microglia) and glial fibrillary acidic protein (GFAP) (astrocyte) immune-positive cells showed an increase in the dorsal horn of the spinal cord, concomitantly with a decrease of pain threshold and a glia density increase in various supraspinal sites [88]

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A representative example is morphine(come from Papaveris Pericarpium ) [36], which undergoes biotransformation via UDP-glucuronosyltransferase 2B7 (UGT2B7) to form pharmacologically active glucuronidesprimarily morphine-3-glucuronide and morphine-6-glucuronide (Fig

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