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Taken together, these recent findings have uncovered a mechanistic relationship between epigenetic dysregulation and several signaling pathwaysmTOR, WNT, Notch, and BDNF-TrkBin ASD development to pave the way for novel therapeutic developments to alleviate ASD symptoms (Figure 3)
ESCs can differentiate into all derivatives of the three primary germ layers [11, 97]
Especially, to limit the burden and toxic side-effects on off-target tissues
Strohm et al., 1995
