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Serious Risks : Carbamazepine carries boxed warnings for SJS/TEN (linked to HLA-B*15:02) and blood disorders

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Glossary HFD high-fat diet STM swertiamarin RG (R) -gentiandiol SG (S) -gentiandiol NAFLD Non-alcoholic fatty liver disease NASH non-alcoholic steatohepatitis HCC hepatocellular carcinoma ESI + positive ionisation mode and ESI negative ionisation mode UPLC-Q-TOF/MS Ultra Performance Liquid Chromatography-Quadrupole-Time Of Flight-Mass Spectrometry KEGG Kyoto encyclopaedia of Genes and Genomes TCM Traditional Chinese Medicine LC-MS Liquid Chromatograph Mass Spectrometer TC total cholesterol TG triglyceride ALT alanine aminotransferase AST aspartate aminotransferase LDL-C low-density lipoprotein cholesterol HDL-C high-density lipoprotein cholesterol MDA malondialdehyde SOD superoxide dismutase GSH-PX glutathione peroxidase HE hematoxylin-eosin AD asymmetric dihydroxylation UPLC ultra-performance liquid chromatography QC Quality Control PCA principal component analysis PLS-DA partial least squares discriminant analysis OPLS-DA orthogonal partial least squares discriminant analysis VIP variable importance in projection value ANOVA analyzed by one-way analysis of variance CDO Cysteine dioxygenase References 1 AhnC