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15-PGDH degradation leads to PGE2 accumulation and excretion to the tumor microenvironment, resulting in aggravating inflammation [46, 47]

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, Liu, H.T

Dissection of the three vastus muscles was performed at an average distance of 12 mm 3 mm measured from the apex of the greater trochanter, with an average femur length in the evaluated rats of 40 mm 5 mm, after which muscle retraction was observed distal to the iliac bone and distal and anterior to the femoral bone, with the appearance of a large defect between the dissected ends (Figure 1)