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BV has been used as a therapeutic agent in Korea and Eastern Asia since ancient times, even before the common era, where it was administered through injections or live bee stings to treat various conditions such as back pain, tumors, arthritis, and multiple sclerosis (44)

For example, several inorganic nanomaterials, including metal chalcogenide nanoparticles, hybrid metal nanoparticles, and single-atom metal nanoparticles, can act as GSH peroxidase-mimicking nanozymes to exhaust intracellular GSH in cancer cells ( 2 O 2 , realizing tumor-specific catalytic therapy with response to the TME featuring overexpressed GSH and H 2 O 2 (Yin et al., 2019)