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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 254.Nallathambi R, Poulev A, Zuk JB, Raskin I

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