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Description
Pediatr Surg Int 18:435437
In the healing of the perforated stomach in the first 15 min, there was initially elevated NOS-2 and decreased VEGFa, then elevated NOS-2 and decreased VEGFa, then elevated COX-2, NOS-1, NOS-2, NOS-3, and then elevated COX-2, NOS-2, and decreased NOS-3 gene expression [144]
The Human Evidence: Promising but Limited Despite decades of animal research, fewer than 30 people have been studied in published human trials as of early 2026
Mild burning, redness, or a small bump can happen and typically resolves quickly
