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Relationship between malondialdehyde serum levels and disease features in a full characterized series of 284 patients with systemic lupus erythematosus

Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin J-P, Sutton RB, Avan P, Krishnakumar SS, Rothman JE, Dulon D, Safieddine S, Petit C

As an extension of the above, the brains high metabolic rate and oxygen consumption make it vulnerable to oxidative stress, which can lead to aging and neurodegenerative diseases like Alzheimers and Parkinsons Disease

The other ROS-increasing conditions, such as inflammation, dyslipidemia, and upregulation of the renin-angiotensin system (blood pressure regulation by the hormone system) all contribute to increased markers of oxidative stress