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Figure 1 Paracetamol for the Early Management of COVID-19: A Critical Viewpoint As discussed above, a precautionary principle regarding the risk of bacterial superinfections and of ACE2 overexpression was the main reason for the decision to discourage the use of NSAIDs (Micallef et al., 2020a

Furthermore, the inhibitory molecules of NRF2, KEAP1, showed reduced levels (Fig

[53] studied the potential role of inflammatory, metabolic, liver damage, and iron metabolism mediators on the inverse association between HCC risk and coffee consumption, as suggested by the reduction in IL-6 levels, a biomarker of inflammation and innate immunity, together with reduced hepatocellular and cholestatic damage biomarkers, i.e., GLDH (glutamate dehydrogenase), ALT (alanine aminotransferase), AST (aspartate aminotransferase), GGT (-glutamyl transferase), and bilirubin