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Redox Biol 54:102382 Hu Z et al (2020) VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

The active component, reduced glutathione, participates in the tricarboxylic acid cycle and glucose metabolism in the body, promoting the generation of high energy and acting as a coenzyme

However, in two recent randomized clinical trials, Skinner et al (109) and Tsakiridis et al (110) reported poorer outcomes for patients with NSCLC treated with metformin in combination with radiotherapy, suggesting that the addition of metformin to radiotherapy did not improve OS in patients with NSCLC and increased toxicities, which contrasts the results of previous studies

These three diseases also ranked among the top four in both the absolute number and relative proportions of DHT-utilizing trials during the 20212024 period (Supplementary Fig