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A basic spreadsheet or notebook tracking: daily dose and time, weekly weight, bi-weekly measurements, and subjective notes provides sufficient data without excessive burden

Cherney K

Conclusions and perspective Almost 90 years after its initial discovery, NAD + is emerging as a central metabolite in the ageing field, and NAD + level decline is becoming an established feature of several age-associated diseases

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)