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The level of collagen hydrolysis product hydroxyproline suggested that H 2 O 2 accelerated collagen hydrolysis, while RGD-GHK prevented more collagen from degradation compared with the action of GHK, as shown in Figure 5A

Aberrant ER Ca 2+ homeostasis is associated with stress and the unfolded protein response (UPR) [44], thus we examined hallmarks of UPR, Xbp1 splicing and Chop/Ddit3 and Gadd34/Ppp1r15a expression but could not discern UPR activation (Supplementary Fig

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M1 macrophages enhance inducible nitric oxide synthase (NOS2 or iNOS) expression, thereby promoting NO production from L-arginine (79)