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How Vitamin B12 Affects Brain Chemistry and Stress Systems Neurotransmitter production B12, together with folate and B6, is essential for the methylation reactions that produce serotonin, dopamine, norepinephrine, and GABA the neurotransmitters most directly involved in regulating mood, motivation, calm, and emotional stability

If any step breaks down (low stomach acid, lack of intrinsic factor, or gut inflammation), much of the B12 passes through unabsorbed

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Normal serum B12 reference range is 200900 picograms per millilitre (pg/mL)