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Thus, targeting oxidative stress is crucial for treating LL-IRI

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, poly ADP ribose polymerase [PARP]), together leading to an increase in the NADH/NAD + ratio and promoting ROS production by mitochondrial respiratory complex I due to NADH overload, eventually resulting in reductive stress (38, 105, 107)

Therefore, NZs could be used to directly stimulate the generation of SN-like structures (mini-SNLSs)