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If a project is on a fast-track schedule, quick decisions are necessary with less time for owners to review or provide input, and owners also generally have less flexibility on final scope items after a GMP is set

270 In addition, aged HSCs accumulate gene mutations, and HSC clones carrying these mutations gradually dominate hematopoiesis owing to their proliferative advantages, forming clonal hematopoiesis, which is the most important precursor lesion of myeloid malignancies

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Amyotrophic Lateral Sclerosis (ALS) is also closely associated with ferroptosis
