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This impairment compromises mitochondrial ATP production, resulting in cellular energy deficits (Siddiqui et al., 2016)

Morito N, Yoh K, Itoh K, Hirayama A, Koyama A, Yamamoto M et al

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The most common of them include Cu 2+ /Zn 2+ superoxide dismutase 1 ( SOD1 ), TAR DNA-binding protein 43 ( TARDBP) , fused in Sarcom a ( FUS ) , and chromosome 9 open reading frame 72 ( C9orf72) genes, involved in protein homeostasis and RNA metabolism [72,73,74,75]