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Acknowledgements Not applicable Abbreviations CMAP Compound motor action potential CNS Central nervous system ECM Cone-extracellular matrix egr-1 gene Early growth response-1 gene EMG Electromyography FAK Focal adhesion kinase GLP Good laboratory practice HNE 4-Hydroxynonenal HPLC High-pressure liquid chromatography JAK-2 Janus kinase 2 LD1 Lethal dose 1 LTB4 Leukotriene B4 MPO Myeloperoxidase MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MUP Motor unit potential naB2 Nerve growth factor 1-A binding protein-2 NSAIDs Non-steroid anti-inflammatory drugs SCI Spinal cord injury TXB2 Thromboxane B2 Authors contributions DP, DK, DD, GB, SS, and PS performed the experiments

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Researchers believe that increased cAMP levels may activate protein kinase A (PKA), which appears to be a key intracellular signaling molecule