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Description
Abstract Background: Cognitive impairment is an important cause of disability and death among the elderly
While LPS exposure alone resulted in a 59% increase in oxidized DCF (a measure of ROS) compared to control cells, pretreatment with GHK-Cu at concentrations of 1, 5, and 10 M significantly decreased ROS production
Its unique ability to activate the HGF/c-Met pathway, promote neurogenesis, and modulate glutamate neurotransmission sets it apart from traditional neurotrophic agents
EVIDENCE GRADES Well-characterized small-molecule inhibitor of nicotinamide N-methyltransferase
