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4).2729 Lentigines or generalized freckles, which appear progressively from 4 or 5 years of age, are much more characteristic of LEOPARD syndrome than CaLS, but they may be similar to those that present in patients with NF1

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FIGURE 3 3.1 The effect of uremic toxins The progression of CKD is accompanied by the accumulation of diverse uremic toxins, which significantly accelerates the process of eryptosis

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