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[DOI] [PubMed] [Google Scholar] Fitzpatrick PJ, Ports TA, Yock PG

In these models, varicocele induction has been associated with increased inflammatory cytokine expression, decreased eNOS activity, and impaired endothelial function in penile tissue ( The AGERAGE axis may also contribute to endothelial injury through oxidative and inflammatory amplification ( Sympathetic nervous system overactivity and catecholamine release may further aggravate endothelial and vascular dysfunction (128, 129)

[DOI] [PubMed] [Google Scholar] 131.Barnes CA, Markowska AL, Ingram DK, Kametani H, Spangler EL, Lemken VJ, Olton DS

This is of primary importance, as most Rett mutations occur de novo, and the disease is usually diagnosed when the symptoms are present, which also means that any therapeutic intervention will be administered to Rett patients after disease onset