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Decreased GSH levels have been shown to activate NF-kB, further impairing mitochondrial function and creating a vicious cycle
Nrf2 is a transcription factor that regulates the expression of antioxidants and anti-inflammatory genes
315 Bimolecular outer-sphere electron-transfer processes are generally slower than inner-sphere electron-transfers but can provide a viable reduction mechanism for platinum(IV) agents in which ligands that are capable of forming a bridge to an electron transfer agent are trans to firmly bound ligands

The onset and course of Parkinson's disease may be different for each patient