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Besides, clinical and neuroimaging studies, fluorodeoxyglucose positron emission tomography, cerebrospinal fluid biomarkers, and peripheral metabolic profiling all support the notion that metabolic impairment is an early and clinically relevant feature of AD very convincingly

Cargo delivered to lysosomes, such as reactive oxygen species (ROS), aggregated proteins, crystalline substances, or indigestible particles, can impose physical or chemical stress

The search was limited to articles published in English, encompassing both clinical and observational studies, to ensure the review's relevance and accessibility to the international scientific community

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