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Category 2 substances are specifically identified as raising significant safety concerns
A Phase I Dose-Escalation Study of BGB-A317, an Anti-Programmed Death-1 (PD-1) mAb in Patients With Advanced Solid Tumors

Snaidero, N

Because these thin split-thickness grafts have relatively little tissue requiring revascularization, these grafts are more likely to take. However, since important thermoregulatory end-organ structures, such as the secretory coils and proximal ducts of sweat glands and the reticular cutaneous vasculature, are located deep within the dermis, these structures are not transplanted with the graft onto the wound (748, 749)
