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In the case of infections occurring within the first half of gestation, the result may be fetal death and abortion

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Combination with Inhibitors of Other RTKs and Downstream Effectors RTK Inhibitors Crosstalk between the IGF axis and other RTK signaling pathways (including EGFR, HER2, VEGFR, PGDFR, cMET, and ALK) results in reciprocal compensatory mechanisms that limit response and/or mediate acquired resistance to treatments that target an individual pathway (Fig

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