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ER stress and oxidative stress are interconnected processes that influence a wide array of cellular signaling pathways

One study demonstrated that upregulation of Nrf2-regulated genes was inhibited in insulin-treated cerebral endothelial cells after 6 h of high glucose exposure, suggesting that insulin treatment can prevent or reduce oxidative stress (Arcambal et al., 2019)

This minimizes the risk to the main vial, but introduces its own set of challenges regarding the stability of the solution in a plastic syringe and the increased risk of contamination

Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment