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Description
elegans age, not only does intracellular iron accumulate but the capacity to safely sequester iron in the iron-storage protein ferritin fails
ALA has also been observed to enhance insulin-stimulated glucose uptake in skeletal muscle, thereby improving insulin sensitivity in patients with type 2 diabetes
For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)
HCys : homocysteine
