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Subsequently, the potential targets of the active ingredient and AD-related disease targets were input into the online tool, and 235 potentially relevant targets for the treatment of AD were obtained for further research (Figure 3)

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We next examined immunovascular interactions in PBMCs isolated from patients with COVID-19 and found increased adhesion of PBMCs to human brain endothelial cells in the cohort with long COVID compared to unaffected individuals, which was heightened in the presence of TNF and only modestly affected by blocking antibodies against ICAM-1 and VCAM-1 (Extended Data Fig