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Figure 3 Locally produced melatonin also protects the intramitochondrial environment from oxidative stress since in addition to acting as a direct radical scavenger it also stimulates enzymes, i.e., superoxide dismutase 2 (SOD2) and glutathione peroxidase (GPx), that remove ROS from the mitochondrial matrix (103)

Most clients experience mild warmth or tingling during application, rating discomfort at 2-3 out of 10

doi: 10.1182/blood-2006-01-0291 97 GodalRKeilholzUUharekLLetschAAsemissenAMBusseAet al

This finding suggests that the topical effect of GSSG on the inflammatory response occurs via UV-induced oxidative stress