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20 Mez and colleagues evaluated available case series and grouped CTE symptoms into stages: Stage 1, attention loss and headache, Stage 2 depression and short-term memory loss, Stage 3 cognitive impairment, and Stage 4 poor verbal skill and aggression

Many classical ferroptosis inducers, such as erastin and RAS-selective lethal 3, can target the xCT/GPX4 axis, and these inducers can trigger ferroptosis in cancer cells, suggesting they hold promise in the treatment of cancer [40, 42]

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In addition, CAT (NM_001752.4), SOD1 (NM_000454.4), Gpx (NM_000581.4), ADH (NM_001042765.1), ALDH (NM_000689.4), CYP2E1 (NM_000773.4), Nrf2 (NM_001145412.3), Keap 1 (NM_012289.4), HO-1 (NM_002133.2), and GAPDH (NM_001256799.3) were used as target genes in the HepG2 cells