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Our work emphasises the importance of developing drug-like GPX4 inhibitors, to investigate exploiting this vulnerability in the clinic
Progress and current status of molecule-targeted therapy and drug resistance in gastric cancer
PMID 12749845
Figure 1 Reduction of ubiquinone and Vitamin E derivatives to antioxidant forms Ubiquinone The reduction of CoQ derivatives of various chain lengths by NQO1 has been examined in both artificial and natural membrane systems (Beyer et al., 9 and CoQ 10 in unilamellar or multilamellar vesicles and protect membrane components from free radical damage and lipid peroxidation
