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If you are not receiving the desired outcome with your treatment and a particular drug, consult your doctor because he may increase the dosages of the drug, recommend an addition of a second or third drug or recommend an entirely different drug type

128 They determined the brain-targeting efficiency after intranasal administration of a methotrexate solution (free MTX), methotrexate-loaded ISG (MTX-ISG), methotrexate-loaded niosome (MTX-N), and MTX-N-loaded ISG (MTX-N-ISG)

Data points represent adjusted % change from baseline mean, where adjustment is for subscore baseline value and treatment

This new peptide has produced positive outcomes in patients, with doses typically ranging from 250 to 500 micrograms per day 3