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A recent study has implicated an effect of LA on MLC through inhibition of pMLC (47)

292 In addition, intermittent hypoxia induces the sympathetic nervous system to increase vascular resistance, down-regulates expression of the kallikrein-kallistatin vasodilator pathway, and activates the renal renin-angiotensin-aldosterone system to cause vasoconstriction

Longitudinal studies on the rate of decline in renal function with age