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A quantitative study of the effects of chaotropic agents, surfactants, and solvents on the digestion efficiency of human plasma proteins by trypsin
V.TsyganovV
doi: 10.1006/jmre.1999.2001

Cerebral spinal fluid (CSF) is considered the appropriate surrogate to evaluate cerebral CoQ10 status, and in view of the low levels of CoQ10 present in this matrix, only highly sensitive analytical techniques such as HPLC-ED and tandem mass spectrometry are appropriate for this analysis [60]
