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IGF-1 also promotes VEGF expression by activating multiple signaling pathways, such as PI3K/Akt and MAPK/ERK, thereby stimulating angiogenesis essential for follicular growth [32]

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An FDA database shows 40 people have reported adverse reactions to retatrutide since 2024, including cardiac issues, appendicitis, and blurred vision

Following this point, it comes as no surprise that mitochondrial metabolism is highly active in virtually all tumors (i.e., cancer cells, stroma, or both), and investigators have begun targeting these pathways to explore potential efficacy