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At a physiologic pH of 7.4, 18 % of chloroquine is monoprotonated but still soluble in lipid and able to traverse cell membranes

[21] SODs catalyze the production of O 2 and H 2 O 2 from superoxide (O 2 ), which results in less harmful reactants

AMPK activation enhances the expression of antioxidant enzymes, such as superoxide dismutase, NADH oxidase, and xanthine dismutase (Lin et al., 2015)

By piecing together how Dsup functions at ever-more-precise levels, scientists can then use it as a blueprint for building other types of proteins "better versions of Dsup" that are even more effective at protecting cells from DNA damage, Kadonaga said