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The enzyme adenylate-activated protein kinase (AMPK), which acts as a sensor of cellular energy levels, influences ferroptosis by facilitating the phosphorylation of acetyl coenzyme A carboxylase (ACC) and the production of polyunsaturated fatty acids (35)

Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)

doi: 10.1016/j.jaci.2021.10.003 [DOI] [PubMed] [Google Scholar] 126.Wood LG, Li Q, Scott HA, et al

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