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An adaptor protein called autosomal recessive hypercholesterolemia (ARH), after the disorder that permitted its discovery (see also the following text), couples the LDLR to the endocytic machinery, permitting LDLR internalization

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Alternating injection days (e.g., Lipo B Monday, Lipo C Thursday) maintains overlapping biochemical coverage across the week rather than front-loading both pathways on one day