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Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22

Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV, et al

A large amount of evidence shows that the activation of the pyroptosis system in ALD includes the classical pathway of caspase-1 activation induced by the synergistic action of ATP, uric acid and ROS, and the non-classical pathway of caspase-4/5/11 activation triggered by lipopolysaccharide (LPS) (Liu et al., 2022

Some reports ( Reference Betz, Ren and Ennis 53 Reference Seekamp, Hultquist and Till 56 ) have indicated that riboflavin can alleviate oxidative injuries in these situations, probably through its ability to scavenge free radicals
