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17 A liver aspirate that reveals more than 80% fatty infiltration of the hepatocytes may be used for presumptive diagnosis of HL

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

Financial support This study was in part supported by NIMH [P50MH136297 (AkS), P50MH094268 (AkS), and R01MH107730 (AkS)], Murakami-Johns Hopkins fellowship (SI), and Tokushukai fellowship (SI)

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