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(2011) demonstrated that API (40, 80, and 120 M) induces apoptosis in HCC cells and inhibits cell migration by reducing the expression of stromal proteins and type I collagen

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The other principal sources of NADPH are from the glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase reactions in the pentose phosphate pathway and via the malic enzyme catalyzed reaction which is involved in the mobilization of mitochondrial acetyl-CoA to the cytosol