lack of glutathione is the main cause of premature aging. system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Glutathione dysregulation and the etiology
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Steinmetz, M.P., Berven, S.H., Benzel, E.C., eds

Mono-ubiquitylation The attachment of one ubiquitin moiety to the substrate protein

Because the Jackson Laboratory strain of C57BL/6 J, which lacks the Nnt gene was used in the NZB-129 heteroplasmy studies, it is possible that mitochondrial ROS production caused by the NZB tRNA Arg 9821 insA allele was enhanced on this strain background resulting in enhanced selection against PGCs or primary or mature oocytes with significant levels of the NZB mtDNA and increased ROS production
