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One 2023 systematic review discovered that there was a 2.4 times increased risk of insomnia symptoms with low vitamin B12 levels, with the association more significant in the non-obese, older adults and women

In septic ICU patients with elevated lactate, treatment with vitamin C and thiamine lowered hospital mortality, showing the strongest benefit when both were given together, especially in vasopressor-dependent cases (Byerly et al., 2020)

This process protects dopaminergic neurons, alleviates motor dysfunction, improves mitochondrial function, and reduces oxidative stress and apoptosis, providing a strong theoretical basis for its application in PD treatment (Tan et al

These aforementioned points, with or without therapy, would have a NO background
