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It is driven by intracellular iron accumulation, glutathione (GSH) depletion, and lipid peroxidation in a positive feedback loop ( Figure 1 ) (7)

Even microscopically, it may be impossible to differentiate hepatic nodular hyperplasia from hepatocellular adenomas, and a large sample (wedge rather than needle biopsy) may be required to confirm hyperplasia from well-differentiated HCCs.75, 76, 77 Routine abdominal radiographs are generally unremarkable and ultrasonographic features are inconsistent because of the varied hepatocellular morphologic characteristics and size of the nodules

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lipid compositions having the desired fundamental properties By employing lipid compositions having the desired fundamental properties, little or no energy need be added when mixing the lipid and an aqueous solution to form liposomes