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The importance of BBB integrity and vascular remodeling in neurodegeneration is supported by evidence highlighting their role in disease progression (Sweeney et al

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Topical GHK-Cu Dosing Face and Neck: Concentration: 1 to 3% GHK-Cu in serum or cream base Amount: 2 to 4 drops or pea sized amount Frequency: Once or twice daily Application: Clean skin, allow absorption before additional products Body (hands, chest, arms): Concentration: 1 to 2% GHK-Cu Amount: Enough to cover target area thinly Frequency: Once daily minimum Duration: Ongoing for maintenance

Study limitations Firstly, despite the relatively large sample size and rich demographic data surrounding the cohort, the ROS cohort, from which most of these samples originate, consists of older Catholic nuns, monks and brothers from the United States only