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Due to its fundamental role, it is not surprising that the carnitine homeostasis is strictly regulated ( FIGURE 1 Fatty Acid Oxidation Impairment and the Onset of Kidney Diseases The link between lipid accumulation and kidney disease was suggested for the first time in 1860 by Rudolf Virchow

These findings suggest a potential link between the altered lipid metabolome in aging and the lipid dysregulation observed in AD, highlighting the need to further investigate how age-related lipid changes may contribute to AD pathology