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Vitamin B12 deficiency in DNA synthesis reduction is explained by the folate trapping theory as methyl-tetrahydrofolate.(...) methionine synthase cannot be activated and folate remains as methyl-FH4, which also causes a functional folate deficiency, thus explaining megaloblastic anemia." SOURCE: Interrelation of Vitamin B12 and Folic Acid

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the hypothesized linkage between the action of AngFV analogues and the HGF/c-Met system predicted that like Dihexa and Nlel -AnglV HGF should be able to stimulate dendritic spine growth in dissociated hippocampal neurons