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Notably, this neuroprotective effect was dependent on the presence and activation of MT1, suggesting that mitochondrial MT1 signaling may play a pivotal role in neuronal resilience against HD-related toxicity [67]

For instance, PPI suppresses acute myeloid leukemia progression by activating the PI3K/SREBP-1/SCD1 axis to promote lipid oxidative damage and ferroptosis (Zhou et al., 2024).Yang and his team demonstrated that PPI induces ferroptosis in hepatocellular carcinoma (HCC) cells with elevating intracellular Fe 2+ and ROS levels, depleting GSH, increasing malondialdehyde (MDA), and downregulating xCT and GPX4 expression

In a single-center, randomized, double-blind, placebo-controlled trial conducted at the Emergency Department of a hospital in Brazil, 140 patients with severe COVID-19 infection and oxyhemoglobin saturation of less than 94% or respiratory rate higher than 24 breaths/minute were randomized to receive N-acetylcysteine 21,000 mg (approximately 300 mg/kg) for 20 hours or dextrose 5% (placebo)