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Melasma and UV-induced hyperpigmentation: Oral glutathione-based supplements are clinically used as adjunctive therapy to topical hydroquinone, retinoids, or laser-based melasma treatment oral delivery reaching melanocytes systemically rather than relying on topical penetration through the stratum corneum

Mitochondrial dysfunction, including oxidative stress, apoptosis, and sustained inflammation, play a critical role in the progression of dry eye
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