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Oxidative stress also contributes to endothelial injury, mitochondrial dysfunction, and impaired vascular reactivity

10.1007/s11101-014-9373-1 23 BeyersmannD.HaaseH

The metabolic stress of early lactation cows often derives from Gram-negative bacterial mastitis when the blood-milk barrier is disrupted by inflammatory mediators, or from the gastrointestinal bacterial load when the epithelial barrier is disrupted due to subacute ruminal acidosis or leaky gut induced by heat stress or other challenges [9]

coli by heat (Fig
