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Degradation of IAPs and NIK stabilisation has been extensively described by drugs called SMAC mimetics [66, 67], nonetheless degradation of IAPs and subsequent NIK accumulation was still observed when caspase-independent cell death was induced in the absence of intermembrane space proteins SMAC and OMI [38]

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H., Koh, B., Ndubuisi, M

"While we acknowledge your response that an abrupt shortening of the enrollment period led to challenges and mistakes, your response is inadequate because, regardless of the length of the enrollment period, you are still responsible for ensuring that subjects meet protocol-specified eligibility criteria before you enroll them into the study," said FDA